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MOTS-PWMitochondrial-derived peptide
16AA
12S rRNA open-reading-frame identityMitochondrial

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MOTS-C Research Peptide

Price range: $43.00 through $114.00

MOTS-c is a mitochondrial-derived research peptide studied in controlled laboratory environments. Researchers use this peptide in structured studies focused on mitochondrial signaling and cellular response pathways.

  • Mitochondrial-derived peptide composed of 16 amino acids
  • Studied in laboratory research focused on mitochondrial and nuclear signaling
  • Suitable for controlled and repeatable research workflows

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Description

MOTS-c Research Peptide

MOTS-c is a mitochondrial derived research peptide made of 16 amino acids and encoded by mitochondrial DNA. Researchers study this peptide in controlled laboratory settings to better understand mitochondrial signaling and cellular energy related activity. Its defined sequence helps laboratories design repeatable studies under clear and stable research conditions.

Because MOTS-c comes from mitochondrial DNA, researchers use it to study how mitochondria communicate with the nucleus during stress based test models. This peptide shows unique behavior among mitochondrial peptides because it can move into the nucleus under certain test conditions. As a result, research teams can examine how signals from mitochondria affect gene activity inside the cell nucleus.

In laboratory studies, scientists use MOTS-c to explore pathways linked to mitochondrial growth, antioxidant response systems, and cellular adaptation. This focused research approach allows laboratories to study how mitochondrial signals guide cellular responses while keeping strong control over test conditions.

Researchers value MOTS-c for its clear origin, defined structure, and fit within structured research workflows. Its consistent makeup helps reduce variation during testing and supports comparison across studies that involve mitochondrial peptides. In addition, its predictable handling makes it suitable for long term laboratory research projects.

Ongoing research continues to include MOTS-c in peptide based laboratory studies. Its mitochondrial origin, clear sequence, and signaling role make it a useful tool for advanced experimental work focused on mitochondrial and nuclear interaction models.

Important Notice

MOTS-c is provided strictly for research use only. Researchers must not use this product for human or animal use, clinical purposes, diagnostic work, or consumption. Qualified professionals must conduct all research in proper laboratory settings and in line with applicable rules and guidelines.

Additional information

Pack size

10 mg, 40 mg

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What is MOTS-c?

MOTS-c (mitochondrial open reading frame of the 12S rRNA-c) is a mitochondrial-derived peptide (MDP) encoded in the short open reading frame within mitochondrial DNA. It consists of 16 amino acids and is expressed in multiple tissues.

How was MOTS-c discovered?

MOTS-c was first identified in 2015 as part of a class of signaling peptides encoded by mitochondrial DNA rather than nuclear DNA, expanding understanding of mitochondrial communication with the cell nucleus.

What cellular mechanisms are associated with MOTS-c?

MOTS-c engages in mitochondrial-to-nuclear signaling by translocating to the nucleus under metabolic stress and modulating gene expression via pathways such as folate-AICAR-AMPK, which are key regulators of energy metabolism and cellular stress responses.

In what research contexts has MOTS-c been studied?

MOTS-c has been studied in controlled models to explore its role in metabolic regulation, including glucose uptake, insulin sensitivity, and lipid metabolism via muscle signaling pathways and mitochondrial energy regulation.

What biological effects have been observed with MOTS-c in experimental models?

In experimental studies, MOTS-c expression increases with metabolic stress and exercise, and it has been linked to mitochondrial-mediated regulation of skeletal muscle energy use, adaptive metabolic signaling, and response to aging-related changes in metabolism.

Why is MOTS-c of interest in peptide research?

Researchers are interested in MOTS-c because it represents a mitochondrial signal molecule that integrates energy metabolism, stress signaling, and gene regulation. Its discovery has advanced understanding of how mitochondria communicate with the nucleus to influence cellular homeostasis.

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