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FOX-PW-10MGResearch material
FOXO4-DRI
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FOXO4-DRI

$180.00

FOXO4-DRI Peptide is a synthetic research compound intended for controlled laboratory use. Researchers work with this peptide in in vitro settings where consistency, defined structure, and reliable handling are essential.

  • Research peptide studied for FOXO4 and p53 protein interaction analysis
  • Supplied in freeze-dried form to support stable handling and preparation
  • Produced to pharmaceutical-grade quality standards with batch verification

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Description

FOXO4-DRI Peptide for Laboratory Research

FOXO4-DRI Peptide is a synthetic research compound used in controlled laboratory environments. Researchers study FOXO4-DRI to examine interactions between specific protein pathways at the molecular level in non-clinical research models. Because peptide-based studies require well-defined and consistent materials, this compound supports structured in vitro research workflows.

In laboratory settings, scientists work with FOXO4-DRI to observe protein interaction behavior under controlled experimental conditions. As a result, the peptide is commonly included in research designs where repeatability, documentation, and clear data interpretation are important.

Research Applications for FOXO4-DRI

In laboratory research, scientists use FOXO4-DRI to study interactions involving the FOXO4 and p53 protein pathways. These studies focus on molecular binding behavior and signaling interactions within controlled systems. For this reason, FOXO4-DRI supports research designs that aim to isolate and examine specific protein-level mechanisms.

Researchers value this research peptide for its defined structure and consistent composition. Its peptide format allows laboratories to repeat experiments and compare results across multiple conditions. Therefore, FOXO4-DRI supports research approaches that emphasize accuracy, controlled variables, and reproducible study outcomes.

Peptide Formulation and Laboratory Handling

FOXO4-DRI Peptide is supplied as a freeze-dried powder intended for laboratory preparation. Researchers choose this format to support peptide stability and flexible handling within research protocols. Lyophilized preparation also helps maintain material integrity during storage and transport.

Prior to experimental use, laboratories reconstitute the powder according to internal protocols using appropriate research-grade solvents. Careful preparation and handling help preserve peptide integrity and support reliable results across repeated studies.

For storage, laboratories should keep the dry material in a cool, dry place away from direct light. Proper storage conditions help preserve stability throughout the research period.

Quality Standards for Research Peptides

Each batch of FOXO4-DRI Peptide meets pharmaceutical-grade quality standards to support consistency and reliability in research supply. Independent testing and batch documentation allow researchers to review material specifications prior to use. Each shipment includes a Certificate of Analysis that supports batch verification and material transparency.

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What is FOXO4-DRI?

FOXO4-DRI is a synthetic D-retro-inverso peptide designed to perturb the interaction between the FOXO4 transcription factor and the p53 protein. It mimics part of the FOXO4 binding domain but uses D-amino acids arranged in reverse sequence to increase stability and cellular penetration for research applications.

What is the intended mechanism of action of FOXO4-DRI in research settings?

FOXO4-DRI disrupts the FOXO4-p53 protein interaction, causing p53 to be excluded from the nucleus and redirected to mitochondrial apoptotic pathways. This leads to selective elimination of senescent cells in laboratory models without affecting normal cell populations.

What are senescent cells and why are they studied with FOXO4-DRI?

Senescent cells are non-dividing cells that accumulate with age or stress and express markers such as p16, p21, and SASP factors. FOXO4-DRI is used in research to study how disrupting senescence-associated signaling influences cell populations and tissue models, by selectively inducing apoptosis in these senescent cells.

In what types of experimental models is FOXO4-DRI used?

FOXO4-DRI has been studied in in vitro and animal models, including expanded fibroblasts and chondrocytes, where it selectively removes senescent cells, and biochemical assays exploring p53-mediated apoptosis and cellular stress response pathways.

What signaling pathways are associated with FOXO4-DRI activity?

FOXO4-DRI engages pathways involving FOXO4/p53 interaction and apoptotic signaling, including p53 nuclear exclusion and activation of downstream mitochondrial mechanisms. These pathways are studied to understand the molecular regulation of cellular senescence and programmed cell death.

Why is FOXO4-DRI of interest in peptide research?

FOXO4-DRI provides a tool to probe senescence-associated signaling and apoptosis networks at the molecular level. Its design enables researchers to dissect how targeted disruption of protein-protein interactions influences cell viability, senescent cell burden, and related signaling cascades in controlled experimental systems.

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