Description
Epitalon (AEDG) synthetic tetrapeptide research compound (Ala-Glu-Asp-Gly). Subject of studies exploring telomerase activation and telomere maintenance.
Epitalon (AEDG) Tetrapeptide Bioregulator | Simple Peptide Research
Epitalon (AEDG) is a synthetic pineal tetrapeptide (C₁₄H₂₂N₄O₉), approximately 390 Da. This low molecular weight is a factor in research focusing on oral bioavailability for compound delivery.
Core Research Mechanisms:
- Telomere Dynamics: Confirmed hTERT activation and telomere elongation in human somatic cells; independently verified in human fibroblast and epithelial lines.
- Epigenetic Regulation: Binds to DNA/linker histones, regulating chromatin architecture and transcription in aged lymphocyte cultures. Regulates neuronal differentiation gene expression in human stem cells.
- Neuroendocrine Signaling: In senescent rhesus monkeys (Macaca mulatta), administration stimulated evening melatonin production and normalized the circadian cortisol rhythm.
Preclinical & Clinical Findings:
Preclinical data show maximum lifespan extension of 42% in CBA mice and 11-16% in Drosophila melanogaster.
Limited human investigations (using Epitalon or Epithalamin):
- A 15-year cardiovascular study reported a significant reduction in cardiovascular mortality risk and 26.7% improvement in 15-year survival in elderly patients.
- A clinical investigation reported a 90% positive clinical effect in human patients with degenerative retinal lesions (retinitis pigmentosa).
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